A Functional Tyr1306Cys Variant in LARG Is Associated With Increased Insulin Action in Vivo
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چکیده
منابع مشابه
A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo.
Diminished insulin sensitivity is a characteristic feature of type 2 diabetes. Inhibition of insulin action, resulting in reduced skeletal muscle glucose uptake, is mediated in part through stimulation of RhoA activity. One regulator of RhoA activity is leukemia-associated Rho guanine nucleotide exchange factor (LARG). The LARG gene maps to a region on chromosome 11q23-24 that shows genetic lin...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2006
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db05-1331